List of 201+ Unique Chemistry Research Topics 2021

Chemistry is said to be a dry subject that make it challenging task for topic selection. It become very hard for you as a student and scholar to select the topic that should meet not only university requirements but must be unique and novel to get it acceptable for your university dissertation committee. As a Writing agency, we have tasked our chemistry writers to make list of topics that are not previously researched and must be novel in depth and scope. After careful evaluation, we have made the list of following 100 topics that you can select for your chemistry research paper, thesis or dissertations. You can select thesis topics for Organic chemistry, synthesis chemistry, spectroscopy, Chemical engineering, petro chemicals or Quantum mechanics. We have mixed these topics with other close related fields to make these topics unique and valuable to the overall world of knowledge in Chemistry.

  1. Novel azo epoxide derivatives alkylating agents for crosslinking of DNA strands: Synthesis and differential dying performance.
  2. Synthesis, structural characterization and bioactivity of novel heterocyclic alkylating agents for crosslinking of DNA strands.
  3. Synthesis, molecular structural characterization and bioactivity of novel epoxide derivatives alkylating agents for crosslinking of DNA strands.
  4. Design, Quantum mechanical (QM) structural and retrosynthesis of novel heterocyclic alkylating agents for crosslinking of DNA strands.
  5. Quantum mechanical (QM) structural design and synthesis of novel epoxide derivatives alkylating agents for crosslinking of DNA strands.
  6. Dual functional acylating agents for crosslinking of DNA strands: Synthesis, structural characterization and crosslinking performance.
  7. Synthesis, structural characterization and application of novel three membered heterocyclic derivatives alkylating agents for crosslinking of DNA strands.
  8. Novel acylating agents for crosslinking of DNA strands: Design, Quantum mechanical (QM) structural and substrate binding analysis.
  9. Design, Quantum mechanical (QM) structural and substrate binding analysis of novel three membered heterocyclic derivatives alkylating agents for crosslinking of DNA strands.
  10. Differential reactivity performance of novel dual functional acylating agents for crosslinking of DNA strands.
  11. Synthesis and differential reactivity performance of novel three membered heterocyclic derivatives alkylating agents for crosslinking of DNA strands.
  12. Synthesis, structural characterization and bioactivity of novel dual functional acylating agents for crosslinking of DNA strands.
  13. Synthesis, structural characterization and bioactivity of novel three membered heterocyclic derivatives alkylating agents for crosslinking of DNA strands.
  14. Computer aided molecular designing (CAMD) of dual functional acylating agents for crosslinking of DNA strands.
  15. Novel three membered heterocyclic C-N bond carrying derivatives as alkylating agents.
  16. Synthesis, structural characterization and crosslinking performance of novel heterocyclic alkylating agents for crosslinking of DNA strands.
  17. Designing, retrosynthesis and application of novel epoxide derivatives alkylating agents for crosslinking of DNA strands.
  18. Quantum mechanical (QM) structural designing and substrate binding analysis of novel heterocyclic alkylating agents for crosslinking of DNA strands.
  19. Novel epoxide derivatives alkylating agents for crosslinking of DNA strands: Design, Quantum mechanical (QM) structural and substrate binding analysis.
  20. Synthesis and differential reactivity performance of novel heterocyclic alkylating agents for crosslinking of DNA strands.
  21. Taxane family microtubule disassembly inhibitor drug molecules: Molecular structural characterization and stereochemical analysis using two dimensional 2D-NMR COSY techniques.
  22. Two dimensional 2D-NMR HETCOR techniques for characterization and stereochemical analysis of diterpenes and taxane microtubule disassembly inhibitor drug molecules.
  23. 2D-NMR NOESY techniques for stereochemical analysis of Taxane family microtubule disassembly inhibitor drug molecules.
  24. Molecular structural characterization and MALDI-TOF HR-MS fragmentation analysis of Taxane family microtubule disassembly inhibitor drug molecules
  25. Computer aided molecular designing (CAMD), Quantum mechanical (QM) and binding interaction analysis of chemioselective novel phosphonyl derivatives for inhibition of acetylcholinesterase (AChE).
  26. Retrosynthesis and molecular structural characterization of chemioselective novel phosphonyl derivatives for inhibition of acetylcholinesterase (AChE).
  27. Chemioselective novel derivatives for inhibition of Butyrylcholinesterase (BChE): Computer aided molecular designing (CAMD), Quantum mechanical (QM) and binding interaction analysis.
  28. Inhibition of Butyrylcholinesterase (BChE): Synthesis and molecular structural characterization of chemioselective novel derivatives.
  29. Dimethoate derivatives for inhibition of acetylcholinesterase (AChE): Computer aided molecular designing (CAMD), Quantum mechanical (QM) and binding interaction analysis of chemioselective.
  30. Retrosynthesis and molecular structural characterization of chemioselective novel dimethoate derivatives for inhibition of acetylcholinesterase (AChE).
  31. Ladostigil derivatives for inhibition of Butyrylcholinesterase (BChE): Computer aided molecular designing (CAMD), Quantum mechanical (QM) and binding interaction analysis.
  32. Structural characterization of chemioselective novel Ladostigil derivatives for inhibition of Butyrylcholinesterase (BChE).
  33. Novel derivatives of dialifor for inhibition of acetylcholinesterase (AChE): Computer aided molecular designing (CAMD), Quantum mechanical (QM) and binding interaction analysis.
  34. Binding energy calculation, retrosynthesis and molecular structural characterization of chemioselective novel dialifor derivatives for inhibition of acetylcholinesterase (AChE).
  35. Tacrine derivatives for inhibition of Butyrylcholinesterase (BChE): Computer aided molecular designing (CAMD), binding interaction analysis.
  36. FAB and SIMS HR-MS based structural characterization and fragmentation analysis of Taxane family microtubule disassembly inhibitor drug.
  37. Vinca alkaloids family microtubule assembly blocker drug molecules: Analysis using two dimensional 2D-NMR COSY techniques.
  38. Two dimensional 2D-NMR HETCOR techniques based stereochemical analysis of Vinca alkaloids family microtubule assembly blocker drug molecules using
  39. Synthesis, structural characterization and application of novel azo glycol chromophores.
  40. Novel azo polyol derivatives: Synthesis, structural characterization and application.
  41. Azo -N=N- glycol chromophores: Design, Quantum mechanical (QM) structural and substrate binding analysis.
  42. Noncovalent bonding with substrate analysis of novel polyol chromophore derivatives.
  43. Differential dying performance of novel azo glycol chromophores on polymeric substrates.
  44. Synthesis and differential dying performance of novel azo polyol derivatives on polymeric substrates.
  45. Novel bioactive azo esters chromophores: Synthesis, structural characterization.
  46. Biazo derivatives: Synthesis, structural characterization and bioactivity.
  47. Chromatic properties of designed novel poly azo glycol chromophores.
  48. Design, Quantum mechanical (QM) structural and retrosynthesis of novel azo polyol derivatives.
  49. 2D-NMR NOESY techniques for molecular structural characterization and stereochemical analysis of Vinca alkaloids family microtubule assembly blocker drug molecules.
  50. MALDI-TOF HR-MS techniques-based fragmentation analysis of Vinca alkaloids family microtubule assembly blocker drug molecules.
  51. FAB and SIMS HR-MS techniques for molecular structural characterization and fragmentation analysis of Vinca alkaloids family microtubule assembly blocker drug molecules.
  52. Chemioselective reactivity of novel Tacrine derivatives for inhibition of Butyrylcholinesterase (BChE).
  53. Azo -N=N- epoxide chromophores and their reactivity with polymeric substrates: Synthesis, structural characterization and application.
  54. Novel azo aziridine derivatives for application natural and synthetic polymeric substrates.
  55. Substituted azo -N=N-reactive epoxide chromophores.
  56. Azo –N=N- aziridine derivatives: Computer aided molecular design (CAMD), Quantum mechanical (QM) structural and polymeric substrate binding analysis.
  57. Biaziridine derivatives for crosslinking applications in polymeric substrates.
  58. Anthraquinone glycol chromophores for noncovalent polymeric binding: Synthesis, structural characterization and application.
  59. Polyol bonded Anthraquinone chromophoric polyol derivatives.
  60. Derivatives of substituted anthraquinone chromophores for angiography applications.
  61. Design, Quantum mechanical (QM) structural and substrate binding analysis of novel glycol derivatives bonded with chromophore for inter chain non covalent binding.
  62. Synthesis and differential dying performance of novel anthraquinone glycol chromophores on polymeric substrates.
  63. Molecular structural analysis, binding behavior and synthesis of novel anthraquinone glycol derivatives for polymeric substrates through Goldberg reaction.
  64. Fused polyaromatic molecules: Design, retrosynthesis, structural characterization and bioactivity.
  65. Synthesis, structural characterization and bioactivity of novel derivatives of benzoic acid derivatives.
  66. Epoxide bonded azo –N=N- chromophores: Synthesis and differential dying performance on carbohydrate polymeric substrates.
  67. Aziridine bonded chromophoric derivatives: Differential dying performance of on polymeric substrates.
  68. Bioactive epoxide bonded synthesized chromophores: Synthesis, structural characterization.  
  69. Azo bonded heterocyclic derivatives with bioactive properties.
  70. Design, Quantum mechanical (QM) structural and retrosynthesis of novel azo epoxide chromophores.
  71. Asymmetric Wittig reaction: Design, Quantum mechanical (QM) structural analysis and reaction mechanism.
  72. Retrosynthesis of novel nitrobenzene derivatives.
  73. Oxidation of azo -N=N- bond to azoxy -N(OH)-N(OH)- : Investigation of reaction mechanism by spectroscopy, isotopes, intermediate trapping.
  74. Investigation of reaction mechanism of reduction of azo azoxy -N(OH)-N(OH) to -N=N- bond by spectroscopy, isotopes, intermediate trapping.
  75. Quantum mechanical (QM) calculations including establishment of reaction coordinate diagram of reaction mechanism of oxidation of azo -N=N- bond to azoxy -N(OH)-N(OH)-
  76. Reaction mechanism of reduction of azo azoxy -N(OH)-N(OH) to -N=N- bond by Quantum mechanical (QM) calculations including establishment of reaction coordinate diagram.
  77. Oxidation of chiral alkenes = in polyene chains: reaction mechanism by spectroscopy, isotopes, intermediate trapping.
  78. Investigation of reaction mechanism of reduction of chiral alkenes (=) bonds in polyene chain by spectroscopy, isotopes, intermediate trapping.
  79. Quantum mechanical (QM) calculations including establishment of reaction coordinate diagram of reaction mechanism of oxidation of chiral glycols to C=O.
  80. Reduction of chiral alkenes (=) bonds in polyene chain: Investigation of reaction mechanism by Quantum mechanical (QM) calculations including establishment of reaction coordinate diagram.
  81. Chemioselective conversion of OH to amine -NH2 in a glycol chain by protection and deprotection of selective OH groups on polyhydric alcohol chain.
  82. Conversion of OH to amine -SHin a glycol chain by protection and deprotection of selective OH groups on polyhydric alcohol chain.
  83. OH to -PR3 in a glycol chain: Chemioselective conversion by protection and deprotection of selective OH groups on polyhydric alcohol chain.
  84. Controlled oxidation of alcohol ROH groups to aldehydes CHO by use of a novel designed and synthesized designed organometallic RM catalyst.
  85. Confirmation of Reaction mechanism of Hoffmann reaction of chiral amides RCONH2 to amines R-NH2 through step-by-step intrinsic reaction coordinate (IRC) calculation.
  86. Curtis rearrangement reaction of chiral amides RCONH2 to amines R-NH2: Confirmation of Reaction mechanism through step-by-step intrinsic reaction coordinate (IRC) calculation.
  87. Dynamic NMR spectroscopic and QM based conformation analysis on impact of alkyl substitution on adjacent heterocyclic three membered rings and application in drug molecular synthesis.
  88. Impact of alkyl substitution on adjacent anhydride rings and application in drug molecular synthesis: Dynamic NMR spectroscopic and QM based conformation analysis on
  89. QM based conformation analysis on impact of aryl substitution on adjacent strained rings.
  90. Impact of aryl substitution on adjacent acyl bond C=O containing rings: QM based conformation analysis 
  91. Novel alkyl substituted crown ether solvents with controlled polarity, inter space for anion and solvation properties.
  92. Cyclic ring containing crown ether solvents with controlled polarity, inter space for anion and solvation properties: Design and Synthesis.
  93. Ionic sulfonate ion containing crown ether solvents: Design and Synthesis.
  94. Design and Synthesis of halide containing crown ether solvents with controlled polarity, inter space for anion and solvation properties.
  95. Nitro group – NO2 containing crown ether solvents with controlled polarity, inter space for anion and solvation properties.
  96. Design and Synthesis of nitrile -CN group containing crown ether solvents with controlled polarity, inter space for anion and solvation properties.
  97. NR4 Tert-amine group containing crown ether solvents with controlled polarity and solvation properties.
  98. Design and Synthesis of alkoxy group OR containing ether solvents for ionic solvation properties.
  99. Heterocyclic aryl group containing crown ether solvents with controlled polarity, inter space for anion and solvation properties.
  100. Imidazole biphenyl derivatives for ACEI and ACEII inhibition.
  101. Quantum mechanical (QM) binding interaction analysis of H2S in the refining of petroleum with imidazolium CF3 substituted sulfate ionic liquid.
  102. Refining of petroleum with (ionic liquid): Quantum mechanical (QM) binding interaction analysis of separation of H2S gas.
  103. A binding interaction analysis of H2S with petroleum for the refining purpous by using Quantum mechanical (QM) approach.
  104. A study on Imidazolium amide ionic liquid:  Quantum mechanical (QM) binding interaction analysis of H2S in the refining of petroleum.
  105. Refining of petroleum through imidazolium acetate ionic liquid: A computational binding interaction study of H2S in the refining of petroleum.
  106. Biological active Nanoparticles from Silver Ag.
  107. Gold Au nanoparticles designing for various medical applications.
  108. Design and modification of dextrose polymer for oil sorbent material to enhance the absorption of hydrophobic substance.
  109. Enhancement of porous properties in silica Si composite aerogels to achieve supper sorbent properties for oil.
  110. Surface modification of cellulose by conversion of -OH to acetate ester and analysis through spectroscopic and scanning electron microscopy (SEM).
  111. refining of petroleum through imidazolium halide ionic liquid: A Quantum mechanical (QM) binding interaction analysis for the separation of H2S.
  112. Surface modification of cellulose by conversion of -OH to alkene and analysis through spectroscopic and scanning electron microscopy (SEM).
  113. Spectroscopic and Imaging analysis of surface modified carbohydrate polymer by conversion of -OH to sulfonate ester.
  114. Design and synthesis of polycyclic alkyl group-based copolymer for enhancement of oxygen permselectivity.
  115. Design and synthesis of multifunctional nanoparticles from noble metals: A Novel Nanomaterial for Various Medical Applications and Biological Activities.
  116. CF3 substituted pyridinium sulfate ionic liquid: Binding interaction analysis of H2S.
  117. Refining of petroleum by removal of H2S in the refining of petroleum with aromatic pyridinium phosphate ionic adduct.
  118. Structural modification of polypropylene based oil sorbent material for enhance the absorption of hydrophobic substance.
  119. A Quantum mechanical (QM) based computational study for the refining of petroleum by using pyridinium sulfonate ionic liquid for H2S impurities.
  120. Imidazolium sulfonate ionic liquid: Quantum mechanical (QM) binding interaction analysis of H2S in the refining of petroleum.
  121. Fully oxidized graphene derivative supported catalysts for fuel cells: Design, Synthesis, catalytic properties and applications in reactions.
  122. Partially oxidized graphene derivative supported catalysts for fuel cells: Design, Synthesis, catalytic properties and applications in reactions.
  123. Alkene substituted graphene derivative supported catalysts for reactions in fuel cells.
  124. Design and synthesis and catalytic performance of alkyl R substituted graphene derivative supported catalysts for fuel cells.
  125. Graphene derivative with alkyne substitution as catalysts for reaction inside fuel cells: Design, Synthesis, catalytic properties and applications in reactions.
  126. Chloro Cl substituted graphene derivative supported catalysts applications in exothermic reactions.
  127. Sodium dodecyl sulfate and dioctyl sodium sulfosuccinate surfactant to increase hydrophobic interaction.
  128. Fluorinated substituted graphene derivative supported catalysts for fuel cells: Design, Synthesis, catalytic properties and applications in reactions.
  129. Facile synthesis of Iodo I substituted graphene derivative catalysts.
  130. Pyridinium halide ionic liquid: Quantum mechanical (QM) binding interaction analysis of H2S in the refining of petroleum.
  131. acetate CH3COOR containing pyridinium acetate ionic liquid for binding with H2S in the refining of petroleum. 
  132. CONR2 containing pyridinium amide ionic liquid: Quantum mechanical (QM) binding interaction analysis of H2S. 
  133. Oxidation of -OH to ketone group in surface modification of cellulose: Analysis through spectroscopic and imaging techniques.
  134. Conversion of -OH to ROR for surface modification of cellulose derivatives and analysis through spectroscopic and scanning electron microscopy (SEM).
  135. Bromo Br substituted graphene derivative supported catalysts for fuel cells: Catalytic properties and applications in reactions.
  136. Branched alkyl R substituted catalysts: Synthesis, catalytic properties and applications in fuel cell reactions.
  137. Molecular structural optimization of sodium alkyl carboxylates-based surfactant for hydrophobic interaction in industrial applications.
  138. Zwitterionic based surfactant to increase hydrophobic interaction and their application.
  139. Design, synthesis and application of novel imidazole ionic liquid for the separation of CO2 from natural gas
  140. Separation of H2S from natural gas: Design, synthesis and application of novel imidazole ionic liquid.
  141. Carboxymethyl cellulose blend films as packing material in food industry: Design and modification of molecular structure.
  142. Synthesis of composite for heat insulation based upon novel designed linear alkyl polysiloxane Si glass and Aluminum alloys.
  143. Composite for heat insulation based upon branched alkyl substituted polysiloxane Si glass
  144. Partial alkyl polysiloxane Si glass and Aluminum alloys: Synthesis of composite for heat insulation.
  145. Crosslinked polyamide CONR2 derivative for efficient physical performance.
  146. Design, synthesis and characterization of azo –N=N- chromophore bonded carbon nano tube (CNT).
  147. Anthraquinone chromophore bonded carbon nano tube: Design, synthesis and characterization.
  148. Novel designed Nitrile CN alkyl polysiloxane Si glass for incorporation in composite for heat insulation.
  149. Synthesis of composite for heat insulation based upon novel designed aryl alkyl polysiloxane Si glass and Aluminum alloys.
  150. Computer aided molecular designing (CAMD) of novel substituted aryl-based polyamide derivative for efficient physical performance.
  151. Substituted aryl alkyl block polyamide derivative for efficient physical performance: Computer aided molecular designing.
  152. Organometallic polyamide derivative for efficient physical performance.
  153. Branched structure polyamide derivative for efficient physical performance: Molecular designing.
  154. Branched alkyl chain bonded carbon nano tube (CNT) and the impact on physical strength.
  155. Design, synthesis and characterization of linear alkyl chain bonded carbon nano tube and the impact on physical properties.
  156. Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of new alkyl substituted derivatives of poly(pyrrole)s (PPY).
  157. Electromagnetic radiation absorption properties of electron donating and withdrawing groups substituted derivatives of poly(pyrrole)s.
  158. NO2-Ar nitrobenzene chromophore bonded carbon nano tube.
  159. Synthesis and characterization of Substituted aryl ring bonded carbon nano tube (CNT).
  160. Organometallic bond carrying carbon nano tube for enhanced physical performance.
  161. Design, synthesis and characterization of chromophoric azo –N=N- chromophore bonded carbon nano tube.
  162. Small Fe molecules encapsulated carbon nano tube (CNT).
  163. Impact of alkyl substitution on conductive properties of new alkyl substituted derivatives of poly(pyrrole)s.
  164. Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of new alkyl substituted derivatives of polycarbazole.
  165. Radar absorbent material: New alkyl substituted derivatives of polyazepines.
  166. Polyazepines RAM (radar absorbent material): electron donating EDG and withdrawing groups EWG substituted derivatives.
  167. Derivatives of poly(3,4-ethylenedioxythiophene) (PEDOT): Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of electron donating and withdrawing groups substituted derivatives.
  168. Novel alkyl substituted derivatives of Poly(acetylene)s (PAC): Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties.
  169. Synthesis, characterisation and absorption properties of new alkyl substituted derivatives of poly(3,4-ethylenedioxythiophene) (PEDOT).
  170. Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of electron donating and withdrawing groups substituted derivatives of Poly(acetylene)s (PAC).
  171. Impact of alkyl substitution on conductive properties of new alkyl substituted derivatives of Poly(acetylene)s (PAC).
  172. Alkyl R substitution on conductive properties of new alkyl substituted derivatives of polyazepines.
  173. Alkyl substituted derivatives of polyanilines (PANI).
  174. Synthesis, characterisation and electromagnetic radiation absorption properties of electron donating EDG and withdrawing groups EWG substituted derivatives of polyanilines (PANI).
  175. Conductive properties of new alkyl substituted derivatives of polyanilines (PANI).
  176. Alkyl substituted derivatives of poly(thiophene)s (PT).
  177. Conductive properties of electron donating and withdrawing groups substituted derivatives of poly(thiophene)s.
  178. Polycarbazole derivatives: electron donating and withdrawing groups substituted derivatives.
  179. Impact of alkyl substitution on conductive properties of new alkyl substituted derivatives of polycarbazole.
  180. Branched substituted derivatives of poly(thiophene)s: conductive properties.
  181. Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of new alkyl substituted derivatives of poly(p-phenylene sulfide) (PPS).
  182. Impact of alkyl substitution on conductive properties of new alkyl substituted derivatives of Poly(p-phenylene vinylene) (PPV).
  183. Design and development of indium tin oxide (ITO) based organic solar cell with the fullerene derivatives.
  184. Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of new alkyl substituted derivatives of polyindoles.
  185. Impact of alkyl substitution on conductive properties of new alkyl substituted derivatives of poly(3,4-ethylenedioxythiophene) (PEDOT)
  186. Properties of polyindoles containing electron donating and withdrawing groups substituted derivatives of polyindoles: Synthesis, characterisation and electromagnetic radiation absorption applications.
  187. Impact of alkyl substitution on conductive properties of new alkyl substituted derivatives of polyindoles.
  188. Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of electron donating and withdrawing groups substituted derivatives of poly(p-phenylene sulfide) (PPS)
  189. Impact of alkyl substitution on conductive properties of new alkyl substituted derivatives of poly(p-phenylene sulfide) (PPS)
  190. Synthesis, characterisation and electromagnetic radiation (EMR) absorption properties of electron donating and withdrawing groups substituted derivatives of Poly(p-phenylene vinylene) (PPV)
  191. Design and Modification in Phthalocyanine based organic solar cell with structural manipulation for enhance the efficiency
  192. Novel modification in Dye-sensitized solar cell through structural changing in Ru-terpyridine complex.
  193. Zn-terpyridine complex based Dye-sensitized solar cell: Novel modification in through structural changing.
  194. Dye-sensitized solar cell: Novel modification through structural changing in Ir-terpyridine complex
  195. Novel, efficient and cost-effective method for the extraction of heavy metals from water waste of leather industry
  196. Use of nitrogen based heterocyclic compounds as ligand for the Etraction of Chromium from lather industry waste.
  197. Etraction of Chromium from lather industry effluent by Using of oxygen based heterocyclic compounds as ligand.
  198. A comparative study for the increase the efficiency of Dye-sensitized solar cell by changing central metal in M-terpyridine complex.
  199. Efficient and cost-effective method for the extraction of heavy metals from solid waste of leather industry
  200. Enhance Electrochemical and electrocatalytic properties of carboxymethyl cellulose films through structural modification.

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